Smoking Tied to Faster Huntington’s Decline
Analysis of Enroll-HD shows smoking is linked to earlier Huntington’s disease onset in women and faster motor and cognitive decline, supporting cessation advice for HD gene carriers.
In Enroll-HD, smoking is linked to earlier Huntington’s onset in women and significantly faster motor and cognitive decline.
Why This Matters for Clinical Practice
Huntington’s disease is progressive and incurable, so modifiable factors that influence symptom onset and progression are clinically relevant.
Using Periodic Dataset 4 from Enroll-HD, investigators evaluated 2,438 individuals, including 799 presymptomatic carriers with four consecutive annual visits.
The analysis tested whether lifetime and current smoking were associated with conversion to symptomatic disease and with changes in established clinical measures over three years.
Smoking is linked to earlier Huntington’s disease onset and faster decline.
Author's summary: Smoking accelerates Huntington's decline.
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