Nirmatrelvir-Ritonavir Reduces Long COVID Risk in Older Adults, Not Adolescents

Nirmatrelvir-Ritonavir Reduces Long COVID Risk in Older Adults, Not Adolescents

Nirmatrelvir-ritonavir reduced the risk for long COVID in adults aged 50 years and older but not in adolescents.

Treatment of acute COVID-19 with nirmatrelvir-ritonavir is associated with a lower risk of developing long COVID in adults aged 50 years and older, but not in adolescents, according to study results published in Open Forum Infectious Diseases.

Long COVID encompasses more than 200 symptoms ranging from fatigue and shortness of breath to cardiovascular disease and diabetes.

While the antiviral nirmatrelvir-ritonavir is well-established in reducing hospitalization and death in acute COVID-19, its potential to mitigate long-term sequelae remains uncertain.

Researchers conducted a retrospective cohort study using United States HealthVerity claims data to evaluate whether treatment with nirmatrelvir-ritonavir during acute illness reduces long COVID risk across different age groups (12-17, 18-49, 50-64, and ≥65 years).

No direct quote available in the text.

Author's summary: Nirmatrelvir-ritonavir reduces long COVID risk in older adults.

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Pulmonology Advisor Pulmonology Advisor — 2025-10-20

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