Cognition After Acute Hypoxemic Failure Not Affected by High vs Low PaO2 Target
Cognitive impairment levels in ICU patients who had acute hypoxemic respiratory failure were similar in those with PaO2 targets of 60 and 90 mm Hg.
Researchers for the Long-HOT study assessed the effects of a lower vs higher oxygenation target on cognitive and pulmonary functions at 1 year post ICU stay among adults who had experienced acute hypoxemic respiratory failure.
- The Long-HOT study enrolled participants of 2 clinical trials — the Handling Oxygenation Targets in the Intensive Care Unit (HOT-ICU) trial and the Handling Oxygenation Targets in COVID-19 (HOT-COVID) trial.
Study findings published in the American Journal of Respiratory and Critical Care Medicine.
Author summary: Similar cognitive outcomes with low and high PaO2 targets.