Melatonin's Hidden Heart Risk
Researchers have discovered a surprising connection between long-term melatonin use and heart failure in patients with chronic insomnia.
A recent study presented at the American Heart Association's Scientific Sessions 2025 found that taking melatonin for a year or more was associated with a nearly doubled risk of heart failure, over triple the risk of hospitalization for heart failure, and nearly twice the risk of death over five years.
Marketed as nature’s sleep switch, melatonin has become a nightly habit for millions.
The study reviewed data from over 130,000 adults with insomnia, shedding light on the potential cardiac risks of long-term melatonin use.
Author's summary: Melatonin may harm the heart in insomnia patients.